Recombinant Human IL-11
Catalog Number: TL-507
Gene Name Synonyms: Adipogenesis inhibitory factor (AGIF)
Construction: A DNA sequence encoding the human IL-11 (NP_000632.1) was expressed with a polyhistidine tag at the C- terminus.
Species:Human
Expression Host: HEK293 cells
Purity: ≥95 %, by SDS-PAGE and HPLC analyses
Biological activity: The ED50, as determined by measuring in a cell proliferation assay using T11 mouse plasmacytoma cells, is≤2.0 ng/ml, corresponding to a specific activity of ≥5 × 105 IU/mg.
Endotoxin Level: ≤0.02 EU per μg of the protein by the LAL method.
Predicted Molecular Mass: 20 kDa
Amino acids: 184
Form: Lyophilized from sterile PBS, pH 7.4. 6 % - 8 % trehalose is added as protectant before lyophilization.
Stability & Storage: Samples are stable for up to 24 months from date of receipt at 4 ℃ . Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Protein Description
IL-11 is a multifunctional cytokine produced by genetic cells such as fibroblasts, epithelial cells and osteoclasts. It is represented in multiple organs, including thymus, lung, bone, connective tissue and central nervous system. IL-11 stimulates the growth of bone marrow, red blood cells and megakaryotic progenitor cells, thus playing an important regulatory role in the process of hematopoiesis. It also regulates bone metabolism, inhibits the production of pro-inflammatory cytokines, and prevents gastric mucosal damage.
References
- Qiao G, et al. (2018) Biofloc technology (BFT): An alternative aquaculture system for prevention of Cyprinid herpesvirus 2 infection in gibel carp (Carassius auratus gibelio). Fish Shellfish Immunol. S1050-4648(18): 30551-52.
- Chhana A, et al. (2018) Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state. Arthritis Res Ther. 20(1): 208.
- Kuo CL, et al. (2018) Zac1 regulates IL-11 expression in osteoarthritis. Oncotarget. 9(65): 32478-32495.
4. Nam JS, et al. (2018) Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis. Korean J Physiol Pharmacol. 22(5):503-511.
Trial dosage: A customer can apply for up to five samples a year (the actual trial dosage is determined by telephone or email communication).
Scope of use: Samples are limited to testing and research purposes.
Cost: Free for samples, customer is responsible for shipping and handling charges, reference cost is $50 in the US, €60 in the EU, and $50 in other countries.
How to apply: You can apply by telephone or by email (the email application should specify the sample name, item number, contact person, telephone number, consignee address, etc.).
